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20 mg/day PO initially; may be increased to 40 mg/day PO after 2 weeks; a diuretic may be added. Dosing Modifications Renal impairment. CrCl >=40 mL/min: No adjustment needed; CrCl 20 mL/min to ; 40 mL/min: No initial adjustment necessary CrCl; 20 mL/min: Consider lower initial dose and dose not to exceed 20 mg/day Hepatic impairment.

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Apr 18, 2018 . The weighted mean dose of thiazide, in hydrochlorothiazide equivalents, was 90 mg for the high-dose trials and 24 mg for the low-dose trials. In five trials, a beta-blocker was used as first-line therapy in one of the arms of the trial ( Dutch TIA 1993 ; MRC-O 1992 ; MRC-TMH 1985 ; TEST 1995 ; UKPDS 39 1998 )..

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Different Drugs: Thiazide diuretics include: hydrochlorothiazide (usual starting dose 12.5 to 25 mg daily) or chlorthalidone (similar dose range). Loop diuretics include: furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex), torsemide has a rather longer duration and is preferred in patients with heart failure..

https://medicine.georgetown.edu/hypertension-drugs/.

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Farxiga (dapagliflozin): Side effects, dosage, uses, and more.

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